Christina Chang was born and raised in Taipei, Taiwan, by her Chinese-Filipino father and American mother. At 17 she moved to the United States to study Theatre & Film in her mother's home state of Kansas and later studied acting in Seattle, USA. Chang went on to gain a Masters of Fine Arts from the University of Washington in Seattle, where she won her first professional acting job in the play Naomi's Road at the Seattle Children's Theater. From there, she progressed to the off-Broadway production of Tina Landau's the Trojan Women.
Chang later moved to New York City and guest starred in various television programs including Cosby, Guiding Light and As the World Turns. She earned feature film roles in such films as Random Hearts, 28 Days, Deadline and Girls Club Hearts. Chang is best known for her roles on television. She had a regular role on ABC series Dragnet (2003–2004), and played recurring roles on 24 as Dr. Sunny Macer, and as State Attorney Rebecca Nevins on CSI: Miami. In 2010, Chang was cast as a regular in ABC's series No Ordinary Family, but exited after two episodes. She also appeared in Once and Again, Boston Legal, Close to Home, Brothers & Sisters, Private Practice, Suits, and Desperate Housewives. In 2013 she was cast in another recurring role, in the second season of the ABC drama series Nashville, as Megan Vannoy, Charles Esten's character's love interest. In 2014, Chang was cast as regular in the ABC drama pilot Sea Of Fire, opposite Jennifer Carpenter.
Chang's other interests include working with children, following in the footsteps of her mother who is a school counselor. She speaks fluent Mandarin Chinese, has studied the trapeze, and has an interest in social work.