The squad tries to solve a homicide case that is muddied by conflicting evidence; Maura must decide if she is going to take in her recently paroled grandfather; Jane and Casey must decide between their careers and their relationship.
- Angie Harmon as Detective Jane Rizzoli
- Sasha Alexander as Dr. Maura Isles
- Jordan Bridges as Officer Frankie Rizzoli, Jr.
- Lee Thompson Young as Detective Barry Frost
- Bruce McGill as Detective Vince Korsak
- Lorraine Bracco as Angela Rizzoli
- Brian Goodman as Sean Cavanaugh
- Chris Vance as Casey Jones
- Mackenzie Astin as Professor Rick Clark
- Kelly Kruger as Jenny Cabot
- Heather McComb as Leslie Cabot
- Richard Herd as Patrick Doyle, Sr.
- David Blue as Peter Kaufman
- Celia Finklestein as Professor Rhonda Clark
- Mary Jo Catlett as Bunny
- David Figlioli as Prison Guard
- Betty Murphy as Shirley